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progress on FASN and MGLL in the regulation of abnormal lipid metabolism and the relationship between tumorinvasion and metastasis

Jingyue Zhang, Yawen Song, Qianqian Shi, Li Fu

Frontiers of Medicine 2021, Volume 15, Issue 5,   Pages 649-656 doi: 10.1007/s11684-021-0830-0

Abstract: Both enzymes play an important role in lipid metabolism and are associated with tumor-related signalinginvasion and metastasis.migration and invasion.invasion and metastasis and reviews the research progress of the relationship of FASN and MGLL withtumor invasion and metastasis.

Keywords： FASN     MGLL     lipid metabolism     tumor invasion     metastasis    

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Disabled homolog 2 is required for migration and invasion of prostate cancer cells

Yinyin Xie,Yuanliang Zhang,Lu Jiang,Mengmeng Zhang,Zhiwei Chen,Dan Liu,Qiuhua Huang

Frontiers of Medicine 2015, Volume 9, Issue 3,   Pages 312-321 doi: 10.1007/s11684-015-0401-3

Abstract: Therefore, DAB2 has always been regarded as a tumor suppressor gene.However, the role of DAB2 in tumor progression and metastasis remains unclear.the tumorigenicity, whereas DAB2 overexpression enhanced LNCaP cell migration and invasion

Keywords： DAB2     prostate cancer     migration     invasion     acetylation    

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is upregulated by PML/RARα fusion protein and promotes plasminogen-dependent fibrinolysis and matrix invasion

Dan Huang, Yan Yang, Jian Sun, Xiaorong Dong, Jiao Wang, Hongchen Liu, Chengquan Lu, Xueyu Chen, Jing Shao, Jinsong Yan

Frontiers of Medicine 2017, Volume 11, Issue 3,   Pages 410-422 doi: 10.1007/s11684-017-0527-6

Abstract:

Aberrant expression of annexin A2-S100A10 heterotetramer (AIIt) associated with PML/RARα fusion protein causes lethal hyperfibrinolysis in acute promyelocytic leukemia (APL), but the mechanism is unclear. To facilitate the investigation of regulatory association between ANXA2 and promyelocytic leukemia/retinoic acid receptor a (PML/RARα) fusion protein, this work was performed to determine the transcription start site of ANXA2 promoter with rapid amplification of 5′-cDNA ends analysis. Zinc-induced U937/PR9 cells expressed PML/RARα fusion protein, and resultant increases in ANXA2 transcripts and translational expressions of both ANXA2 and S100A10, while S100A10 transcripts remained constitutive. The transactivation of ANXA2 promoter by PML/RARα fusion protein was 3.29±0.13 fold higher than that by control pSG5 vector or wild-type RARα. The overexpression of ANXA2 in U937 transfected with full-length ANXA2 cDNA was associated with increased S100A10 subunit, although S100A10 transcripts remained constitutive. The tPA-dependent initial rate of plasmin generation (IRPG) in zinc-treated U937/PR9 increased by 2.13-fold, and cell invasiveness increased by 27.6%. Antibodies against ANXA2, S100A10, or combination of both all remarkably inhibited the IRPG and invasiveness in U937/PR9 and NB4. Treatment of zinc-induced U937/PR9 or circulating APL blasts with all-trans retinoic acid (ATRA) significantly reduced cell surface ANXA2 and S100A10 and associated reductions in IRPG and invasiveness. Thus, PML/RARα fusion protein transactivated the ANXA2 promoter to upregulate ANXA2 and accumulate S100A10. Increased AIIt promoted IRPG and invasiveness, both of which were partly abolished by antibodies against ANXA2 and S100A10 or by ATRA.

Keywords： annexin A2-S100A10 heterotetramer     PML/RARα fusion protein     plasmin     cell invasion     acute promyelocytic leukemia    

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Effects of miR-200c on the migration and invasion abilities of human prostate cancer Du145 cells and

Runlin Shi,Haibing Xiao,Tao Yang,Lei Chang,Yuanfeng Tian,Bolin Wu,Hua Xu

Frontiers of Medicine 2014, Volume 8, Issue 4,   Pages 456-463 doi: 10.1007/s11684-014-0353-z

Abstract:

microRNAs (miRNAs) have played a key role in human tumorigenesis, tumor progression, and metastasismiRNAs are aberrantly expressed in many types of human cancer; on the other hand, miRNAs can function as tumorof miRNA-200c (miR-200c) on the biological behavior and mechanism of proliferation, migration, and invasionThe proliferation, migration, and invasion abilities of Du145 cells were detected by CCK8 assays, migrationassays and invasion assays, respectively.

Keywords： miR-200c     proliferation     migration     invasion     prostate cancer     Du145 cell     ZEB1    

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Effects of hypoxia inducible factor-1alpha siRNA on the invasion of human Hela cells and expression of

Bin YANG MS , Xianglin YUAN , Yanmei ZOU , Qingsong XI , Guoxian LONG , Qiang FU , Guangyuan HU MM ,

Frontiers of Medicine 2009, Volume 3, Issue 3,   Pages 303-308 doi: 10.1007/s11684-009-0060-3

Abstract: The effects of hypoxia on the invasion and the related protein expression of Hela cells and the roleThe scratch test and the invasion assay were applied to examine the invasion in each group.The expression of HIF-1α, E-cadherin, and β-catenin in tumor grafts was assayed immunohistochemicallyIt was concluded that the effects of hypoxia on the invasion of human cervical cancer Hela cells and

Keywords： hypoxia     actin     β     -catenin     E-cadherin     invasion    

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Heterogeneity of the tumor immune microenvironment and clinical interventions

Frontiers of Medicine 2023, Volume 17, Issue 4,   Pages 617-648 doi: 10.1007/s11684-023-1015-9

Abstract: Heterogeneity of the tumor immune microenvironment and clinical interventions

Keywords： Heterogeneity tumor immune    

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Proteins moonlighting in tumor metabolism and epigenetics

Lei Lv, Qunying Lei

Frontiers of Medicine 2021, Volume 15, Issue 3,   Pages 383-403 doi: 10.1007/s11684-020-0818-1

Abstract: interplay of multiple signaling pathways and restrained by oxygen and nutrient accessibility in the tumorThe signal−moonlighting protein−metabolism axis facilitates the adaptation of tumor cells under varying

Keywords： moonlighting function     tumor metabolism     epigenetics    

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Complex interplay between tumor microenvironment and cancer therapy

Minhong Shen, Yibin Kang

Frontiers of Medicine 2018, Volume 12, Issue 4,   Pages 426-439 doi: 10.1007/s11684-018-0663-7

Abstract:

Tumor microenvironment (TME) is comprised of cellular and non-cellular components that exist withinand around the tumor mass.Given the importance of TME in tumor progression and therapy resistance, strategies that remodel TME

Keywords： tumor microenvironment     therapy response     treatment resistance    

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Immunosuppressive tumor microenvironment contributes to tumor progression in diffuse large B-cell lymphoma

Frontiers of Medicine 2023, Volume 17, Issue 4,   Pages 699-713 doi: 10.1007/s11684-022-0972-8

Abstract: However, the underlying mechanism of alterations in the tumor microenvironments resulting in CAR-T cellSingle-cell RNA sequencing results were obtained from core needle biopsy tumor samples collected fromM2-subtype macrophages were significantly involved in both in vivo and in vitro anti-tumorImmunosuppressive tumor microenvironments persisted before CAR-T cell therapy, during both cell expansionThus, our findings provided a clinical rationale for targeting tumor microenvironments and reprogramming

Keywords： anti-CD19 chimeric antigen receptor T     immunotherapy     diffuse large B cell lymphoma     tumor microenvironment     tumor-associated macrophage     metabolism    

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Progress in tumor vascular normalization for anticancer therapy: challenges and perspectives

Bingxue Shang, Zhifei Cao, Quansheng Zhou

Frontiers of Medicine 2012, Volume 6, Issue 1,   Pages 67-78 doi: 10.1007/s11684-012-0176-8

Abstract: Although the current antiangiogenic drugs reduce the density of tumor blood vessels and result in tumor, which fosters tumor cells to become more aggressive and metastatic.on the pioneering work on tumor blood vessels by several other researchers.roles in tumor neovascularization, growth, and metastasis.Therefore, multiple-targeting of vasculogenic tumor cells and genes may improve the efficacy of tumor

Keywords： angiogenesis     vasculogenesis     neovascularization     tumor     vasculature     normalization     traditional Chinese medicine    

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Natural killer cell lines in tumor immunotherapy

Min Cheng, Jian Zhang, Wen Jiang, Yongyan Chen, Zhigang Tian

Frontiers of Medicine 2012, Volume 6, Issue 1,   Pages 56-66 doi: 10.1007/s11684-012-0177-7

Abstract: genetically modifying NK cell lines by increasing their expression of cytokines and engineering chimeric tumorIn this review, NK cells in tumor immunotherapy are discussed, and a list of therapeutic NK cell lines

Keywords： natural killer cell     natural killer cell line     tumor immunotherapy     genetic modification    

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Nanovaccines for remodeling the suppressive tumor microenvironment: New horizons in cancer immunotherapy

Kai Shi, Matthew Haynes, Leaf Huang

Frontiers of Chemical Science and Engineering 2017, Volume 11, Issue 4,   Pages 676-684 doi: 10.1007/s11705-017-1640-4

Abstract: Specifically, reversing the immune-suppressive effects of the tumor microenvironment, mediated by a variety

Keywords： vaccine     nanoparticle     tumor     immunotherapy     microenvironment    

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carmustine loaded natural extracellular matrix hydrogel for inhibition of glioblastoma recurrence after tumor

Frontiers of Chemical Science and Engineering 2022, Volume 16, Issue 4,   Pages 536-545 doi: 10.1007/s11705-021-2067-5

Abstract: recurrence after tumor resection, both free BCNU and BCNU- poly (lactic-co-glycolic acid) (the ratioThe hydrogel was injected into the resection cavity of a glioblastoma tumor immediately after tumor removalFree drugs were released instantly to kill the residual tumor cells, while drugs in nanoparticles werecontinuously released to achieve a continuous and effective inhibition of the residual tumor cells forThese combined actions effectively restricted tumor growth in rats.

Keywords： BCNU     glioblastoma recurrence     tumor resection     nanoparticles     hydrogel    

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A global synthesis of the effectiveness and ecological impacts of management interventions for species

Frontiers of Environmental Science & Engineering 2023, Volume 17, Issue 11, doi: 10.1007/s11783-023-1741-x

Abstract:

● Spartina abundance decreases over time by chemical control.

Keywords： Plant invasion     Biodiversity     Meta-analysis     Restoration     Salt marshes     Treatment timing    

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Bacteria-mediated tumor-targeted delivery of tumstatin (54-132) significantly suppresses tumor growth

Frontiers of Medicine 2022, Volume 16, Issue 6,   Pages 873-882 doi: 10.1007/s11684-022-0925-2

Abstract: Tumor growth is an angiogenesis-dependent process and accompanied by the formation of hypoxic areas.Tumstatin is a tumor-specific angiogenesis inhibitor that suppresses the proliferation and induces theTreatment with VNP-Tum5 effectively suppressed tumor growth and prolonged survival in the mouse modelThis study is the first to use tumstatin-transformed VNP20009 as a tumor-targeted system for treatmentof melanoma by combining anti-tumor and anti-angiogenic effects.

Keywords： Salmonella VNP20009     tumstatin     B16F10     melanoma     apoptosis     angiogenesis    

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Title Author Date Type Operation

progress on FASN and MGLL in the regulation of abnormal lipid metabolism and the relationship between tumorinvasion and metastasis

Jingyue Zhang, Yawen Song, Qianqian Shi, Li Fu

Journal Article

Disabled homolog 2 is required for migration and invasion of prostate cancer cells

Yinyin Xie,Yuanliang Zhang,Lu Jiang,Mengmeng Zhang,Zhiwei Chen,Dan Liu,Qiuhua Huang

Journal Article

is upregulated by PML/RARα fusion protein and promotes plasminogen-dependent fibrinolysis and matrix invasion

Dan Huang, Yan Yang, Jian Sun, Xiaorong Dong, Jiao Wang, Hongchen Liu, Chengquan Lu, Xueyu Chen, Jing Shao, Jinsong Yan

Journal Article

Effects of miR-200c on the migration and invasion abilities of human prostate cancer Du145 cells and

Runlin Shi,Haibing Xiao,Tao Yang,Lei Chang,Yuanfeng Tian,Bolin Wu,Hua Xu

Journal Article

Effects of hypoxia inducible factor-1alpha siRNA on the invasion of human Hela cells and expression of

Bin YANG MS , Xianglin YUAN , Yanmei ZOU , Qingsong XI , Guoxian LONG , Qiang FU , Guangyuan HU MM ,

Journal Article

Heterogeneity of the tumor immune microenvironment and clinical interventions

Journal Article

Proteins moonlighting in tumor metabolism and epigenetics

Lei Lv, Qunying Lei

Journal Article

Complex interplay between tumor microenvironment and cancer therapy

Minhong Shen, Yibin Kang

Journal Article

Immunosuppressive tumor microenvironment contributes to tumor progression in diffuse large B-cell lymphoma

Journal Article

Progress in tumor vascular normalization for anticancer therapy: challenges and perspectives

Bingxue Shang, Zhifei Cao, Quansheng Zhou

Journal Article

Natural killer cell lines in tumor immunotherapy

Min Cheng, Jian Zhang, Wen Jiang, Yongyan Chen, Zhigang Tian

Journal Article

Nanovaccines for remodeling the suppressive tumor microenvironment: New horizons in cancer immunotherapy

Kai Shi, Matthew Haynes, Leaf Huang

Journal Article

carmustine loaded natural extracellular matrix hydrogel for inhibition of glioblastoma recurrence after tumor

Journal Article

A global synthesis of the effectiveness and ecological impacts of management interventions for species

Journal Article

Bacteria-mediated tumor-targeted delivery of tumstatin (54-132) significantly suppresses tumor growth

Journal Article